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A Pivotal Advance in the Global Fight Against Tuberculosis

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 Tuberculosis (TB), an enduring global health threat claiming millions of lives annually, has encountered a breakthrough at the Indian Institute of Science (IISc). In 2023, researchers unveiled the “whiB7” gene in Mycobacterium tuberculosis (Mtb), offering a potential game-changer in the battle against this persistent disease. Unlocking Mtb’s Secrets Utilising cutting-edge tools, IISc researchers delved into the intricate workings of Mtb, revealing the previously undiscovered gene, whiB7. This gene plays a crucial role in the bacteria’s ability to enter a dormant state within human cells, eluding immune defenses and existing drugs. The discovery opens new avenues for understanding the persistence of TB infections. Targeting WhiB7—A Novel Approach Under the leadership of Dr. Ayesha Khan, the IISc research team proposes a groundbreaking approach to develop drugs specifically targeting whiB7, referred to as “host-directed therapy.” This innovative strategy exploits vulnerabilities in ...